This one came through without my input, so I'm allowed to talk. :-P
I am solidly in the 1B camp, to return to the previous discussion points. The idea is interesting (and I don't find it particularly frightening in itself). Movies are communal efforts to start with, and the selection of audience members with refined taste struck me as eminently sensible and likely to produce, if not brilliant and challenging and troubling art, then at least solid and well-constructed stories. (As the submissions manager, I have perhaps an unusual point of view on why having good taste might be particularly important to an artistic endeavor. I get a LOT of submissions from people who clearly deeply love... well, something, but just being extremely enthused is no guarantee that you will produce anything but crap. You have to study, to read with an eye to deconstruction. Spitting out a variation of all of your favorite things is not likely to produce a good story.) I'm not overly bothered by the idea of using powerful genetic-algorithm software to enhance a product, though I'm skeptical that something like Pixar would be the result. (Dreamworks, absolutely, and the references to "The Mezozoic" definitely sent me that direction rather than toward Pixar.)
However, as has been pointed out, the 'story' aspect here is really, really thin. (A "baked potato" story, if you will; vast and squishy chunks of buttery idea, but only a tiny jacket of what contains the actual vitamins.) The ambiguous ending fell a little flat because of how little Sophia is involved in anything that happens; if you cut her completely out and just had a short PowerPoint presentation explaining the idea of Big Semi, you'd still generate 90% of the discussion in this thread. Now, on the one hand, that's a grand old tradition in science fiction, to write a story that is nothing but an excuse for a man in a lab coat to lecture the audience about some idea the author just read about. But on the other hand, I like to think that SF, as a genre, has developed enough that we can afford to tell proper stories and have Big Ideas. The snippets of character in this story are well-done and quite impressively subtle for their brevity, which is a testament to Ken Liu's skill, but they're really nothing more than a formality, an excuse for the lecture to happen.
Also, I'd like to third the "OMG WHY IS NO ONE TALKING ABOUT THE BRAIN DAMAGE!?" That detail smacks of a last-minute revision; some beta-reader must have asked, "But wouldn't seeing the same movie immediately afterward alter the unconscious reactions and skew the whole process?" And so we get a quick explanation to forestall that complaint, spackle it on and just walk past it really fast when touring the facility, hoping that no one notices. But holy crap, there are so many terrifying ways that sort of thing could go wrong that it really eclipsed the rest of the story for me; it was so obviously a meta-fiction device to try and keep me focused on the question of "Can computers make Art?" that I wasn't able to think about anything else.
("So there's a train rushing toward five people on the tracks, but if you push a lever, it will switch to a track with only one person. Do you push the lever?"
"Of course. One person dying is less awful than five."
"Aha! So now you're on a ledge over the train tracks, and the train is rushing toward five people, but this time all you have is one very large, fat man. If you push him over, the train will hit him and stop, saving the other five. Can you consign him to death when you have to do the killing yourself instead of just pulling a lever!?"
"But if the train is going fast enough to kill five people and not derail, why would one person stop it?"
"They're very small people."
"Wait, they're children? So how old is the fat man?"
"That's not the point!"
"What if I just ask him to jump?"
"He won't."
"Why not? I'd do it. In fact, can't I just jump myself if the fat man is a dick about it?"
"You're not big enough to stop the train."
"But the fat man is? I weigh like two hundred pounds. How fat is he? How can I even push him if he's that superhumanly fat?"
"Look, just assume that he's big enough, that he won't do it himself, that you can't do it, that the five people will definitely all die, that...")