It's not exactly a cigarette in space, but in one of my favorite Outer Limits episodes (original series, in black and white) a very young William Shatner is a pilot who goes into space and is exposed to something that is slowly transforming him into a monster. When he gets back to Earth all the doctors keep offering him a smoke and looking concerned when he refuses, taking it as a sign of his declining condition.
Also- though this is totally off topic- in the same episode, Shatner has a line where he tells his wife he's going into space "...to seek out new life...new experiences...new civilizations... new knowledge." I think Gene Roddenbury saw this one, or had some hand in it. It's sooo close to the Star Trek TOS intro. I dunno the episode title or # or anything, sorry, but if you find it you'll see what I mean.
Sigh- I'm new here, this will be my third post, and two of the three are about William Shatner. I think I need to stretch out a bit more.