Several of my regular ports of call:
www.angels2200.com Currently being rebuilt following a server crash. Stunningly good science fiction webcomic dealing with the crew of a decrepit carrier, being sent into a mission far more complicated and dangerous than they were led to believe. Sort of Battlestar Galactica, but with more humour.
www.warrenellis.com English comic writer and now novelist. His website is currently a rolling research blog of photos, music, movies, current affairs and websites. If you don't like what's on there in the morning, check back at night, chances are it will all have changed.
www.smashingtelly.com A links page describing itself as linking to 'the best free movies and TV programs available on the web'. It's all either google video or youtube stuff and the variety is astonishing. A documentary about ghosts on the London Underground sits next to coverage of the Web 2.0 conference at Davos and just up from The Day The Earth Stood Still. Oh and the Turkish version of Star Wars. Updated daily.
http://www.comics.com/comics/getfuzzy/ Rob's dog Satchel is an amiable, perpetually hungry idiot. Rob's cat Bucky is a 1 foot nothing ball of hate, so angry his ears are back ALL THE TIME. Inspired lunacy and the only website you'll ever see featuring a cat duct taping a phone to himself.
www.marvinsuicide.org Host of one of Resonance FM's regular shows. Not only are they worth your time but Marvin's own website is a vital stop for anyone interested in new music. He's been doing this for over a hundred shows, the first 110 of which are archived on the site with complete track listings and details of where to download the tracks from. Marvin is dedicated to tracking down the best new, free music on the internet and he does a fantastic job of it. An essential site for music fans.
www.shortpacked.com Up until eighteen months ago, I ran an asylum which looked, to all intents and purposes, like a comic shop. Shortpacked, whilst set in a toy shop, gives me regular moments of sweaty palmed recognition as well as making me laugh. A lot.