I'm thinking we (escape pod community) should all try to make our way to San Francisco when this all goes down (on second thought, add a few more select people. I'm going to put Jessica Alba and Rosario Dawson on my RSVP). Here's my reasoning as to why San Fransisco is the greatest Zombie hold out in the world. 
1. San Francisco has a large proportion of homosexual males. This means that a larger part of the zombie pie will have tastes that are far too discriminating for sci-fi geeks... although... Our larger brains may only serve to put us on the top of the overpriced, trendy, zombie menus, completely screwing us. If that were to occur, we'd have...
2. Bridges. By strategically using the Golden Gate and Bay Bridges as choke points, you can minimize the directions from which the zombies can come at you but eventually, you'll have to pull back to...
3. Fisherman's wharf. If you're going to be holed up, might as well do it in a fun place with good food and SEALS!!! Eventually the zombie seals will overtake the cute ones... Anyhoo. The shape of the place would funnel the zombies right down the center. The second level would serve as a great tactical point from which hellfire can be rained down upon the undead. But again, you'll eventually have to pull back to...
4. The Beach!!! YaY! Bonfires lit by perfectly dried, riggored corpses. Champaign looted from local stores. Gentel music played by local musicians and all the bongs and bricks of medical Marijuana will make this spot extra special as you fall asleep to the groans of brain hungry damned. They will of course be kept at bay by a half circle of burning corpses surrounding the secured zone. The perimeter of course will have to be maintained by several people on a rotating basis in order to allow for the final move to...
5. Alcatraz! The perfect Zombie fortress. Although zombies might be able to swim, they would do so too slowly to actually keep them afloat, which means they'd have to walk the distance along the bottom floor to get to the island. However the island of Alcatraz has 2 top notch Zombie defenses.
  a. Swift currents - Enough to wash away any slow moving zombie people, seals or sea horses
  b. Vicious man eating sharks - If the make it into the water and even a quarter of the way, the shark population would explode due to food abundance, repelling the invasion even further
At Alcatraz, every day will be a holiday as we all fall asleep to beautiful sulfury glow of San Francisco ablaze, in our safe, cozy new zombie-proof home.