Well, looks like I'm the first to step out with the hate... I couldn't begin to cover all the fail, but here's some lowlights:
First, the plot was so contrived, not only to throw the cast together (which, considering that we're on a drastically altered timeline starting from JTK's birth, would require the type of predestination that works better in fantasy than SF), but to throw them into situations where they can say their trademark catch phrases. One or two would have been fine, but every five minutes there was a "I'm a doctor, dammit" or a "She cannae take any more."
Also, on top of the usual suspension of disbelief surrounding Starfleet protocols (why exactly are we sending ships full of civillians and officers' families on military missions, or sending essential command personnel on dangerous away missions?), we have the even more glaring question of why this brand-new, state-of-the-art ship, being sent into a crisis situation, on what is essentially its shakedown run, has been almost entirely crewed by cadets; what's even more ridiculous, besides a few somehow all these cadets happen to magically do their jobs better than the seasoned professionals. It's like they took everything that was wrong with Wesley Crusher, then made a whole movie of it, but with the added insult of doing it with characters we actually care about.
(And one more piddling little thing -- all those tubes labelled "inert reactant?" Isn't an inert substance by definition not a reactant?)