I'm with Derego, email subs are nice but the text reformatting can be a pain. It's alleviated a bit by keeping a copy of the text file in the same folder as the main file and only altering it when I make revisions (which I usually don't do once I start submitting). Then I check the modify date for both before the next time, and as long as the text file has a more recent modify-by date then I don't need to redo the process.
I don't really mind web forms, and I really like the ones with shnazzy tracking systems that give you additional information, especially the ones that tell you your number in the queue (like Clarkesworld, Fantasy, Electric Velocipede).