I'm not sure how I feel about this story.
For most of it Minerva's mode of speech bothered. She did not sound like any twelve year old I know. Only towards the end did we learn that her opt was for higher mental acuity. (Typing opt now without a slash is really hard for me

)
I totally bought the idea of a perpetually rebooting, adorable little 6 year old. At that age, and for the first few times it's cute. I'm proud to say that my mind did not immediately catch up with more gruesome ramifications of such an optimization. But it very quickly got old, and I'm glad that the author didn't trouble us with it too many times.
I can understand why Grace did what she did. It wasn't entirely out of love for the kid, but it was also (at least I think) partly because of her dead-end life. Here she is, a middle aged doctor, living alone, trying to find something to latch on to, something to commit herself to, and wondering where her idealism went. Daniel/David landed right in her lap. He is exactly what she needed. The better question is, is she what he needs?
I'm not worried about the ramifications of her blinding him on so little evidence. In a world where children are designed per spec, and a child can regrow limbs a couple of eyes are a piece of cake.
What bothers me is that he will become irrevocably attached to her. She won't even be able to go the bathroom by herself. How does this kid go to school? Meet other people? How can his "mother" have any kind of life without him tagging along all the time.
Worse, she is 40 years older than him. What happens when she dies? (hopefully of old age) How does he carry on?
This was an impulsive decision on her part, and it probably will not turn out too well for either one of them.
But at the very end, my thoughts turn to Minerva.
She was, in my opinion, a much better character. She made a well-informed decision, and could probably stick it out. She is a much more believable character (once I realized she was optimized for being super smart).
The world building was very good. It's true, we don't see enough medical sci-fi, but this one had a very well fleshed-out world. I would like to hear more stories in this world, perhaps staring Minerva.
(A museum paleontologist is too boring for a person like her, she needs to become an armchair detective).