It took me about a month of play to start beating the game, once you do it the first two or three times it gets a lot easier. I'd get back in for group, but finals and final papers are due in the next two weeks, and I sort of need to pass my classes. Just a little bit.
You can't really beat 10k, at least I never could. You can get very far, but there's no real good way to finish it since you can't do much. I'd concentrate on getting a really good maze and some ice towers, but again, it's nearly impossible to win.
I never really liked the Anti-air towers after level 40ish, the squirts @ 5 do a lot more damage, but they also set off the spawns. Go heavy on the squirts, but mix in the other things, especially the pounds when you have a U turn since the extra couple of seconds while they're stunned can save you later in the game and especially with the speedfreaks.